Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Archive
    • Podcast: NC Health Policy Forum
    • Upcoming Scientific Articles
  • Info for
    • Authors
    • Reviewers
    • Advertisers
    • Subscribers
  • About Us
    • About the North Carolina Medical Journal
    • Editorial Board
  • More
    • Alerts
    • Feedback
    • Help
    • RSS
  • Other Publications
    • North Carolina Medical Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
North Carolina Medical Journal
  • Other Publications
    • North Carolina Medical Journal
  • My alerts
  • Log in
North Carolina Medical Journal

Advanced Search

  • Home
  • Content
    • Current
    • Archive
    • Podcast: NC Health Policy Forum
    • Upcoming Scientific Articles
  • Info for
    • Authors
    • Reviewers
    • Advertisers
    • Subscribers
  • About Us
    • About the North Carolina Medical Journal
    • Editorial Board
  • More
    • Alerts
    • Feedback
    • Help
    • RSS
  • Follow ncmj on Twitter
  • Visit ncmj on Facebook
Research ArticlePolicy Forum

Nonalcoholic Fatty Liver Disease

Tyler Thrasher and Manal F. Abdelmalek
North Carolina Medical Journal May 2016, 77 (3) 216-219; DOI: https://doi.org/10.18043/ncm.77.3.216
Tyler Thrasher
clinical trials assistant, Division of Gastroenterology and Hepatology, Department of Medicine, Duke University, Durham, North Carolina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Manal F. Abdelmalek
associate professor of medicine, Division of Gastroenterology and Hepatology, Department of Medicine, Duke University, Durham, North Carolina
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: manal.abdelmalek@duke.edu
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. ↵
    1. Chalasani N,
    2. Younossi Z,
    3. Lavine JE, et al., American Gastroenterological Association, American Association for the Study of Liver Diseases, American College of Gastroenterology
    The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology. 2012;142(7):1592-1609.
    OpenUrlCrossRefPubMedWeb of Science
  2. ↵
    1. Day CP
    Non-alcoholic fatty liver disease: a massive problem. Clin Med (Lond). 2011;11(2):176-178.
    OpenUrlPubMed
  3. ↵
    1. Angulo P
    Nonalcoholic fatty liver disease. N Engl J Med. 2002;346(16):1221-1231.
    OpenUrlCrossRefPubMedWeb of Science
  4. ↵
    1. Newton JL,
    2. Jones DE,
    3. Henderson E, et al.
    Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance. Gut. 2008;57(6):807-813.
    OpenUrlAbstract/FREE Full Text
  5. ↵
    1. Mofrad P,
    2. Contos MJ,
    3. Haque M, et al.
    Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values. Hepatology. 2003;37(6):1286-1292.
    OpenUrlCrossRefPubMedWeb of Science
  6. ↵
    1. Ong JP,
    2. Pitts A,
    3. Younossi ZM
    Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease. J Hepatol. 2008;49(4):608-612.
    OpenUrlCrossRefPubMedWeb of Science
  7. ↵
    1. Stepanova M,
    2. Rafiq N,
    3. Makhlouf H, et al.
    Predictors of all-cause mortality and liver-related mortality in patients with non-alcoholic fatty liver disease (NAFLD). Dig Dis Sci. 2013;58(10):3017-3023.
    OpenUrlCrossRefPubMed
  8. ↵
    1. Argo CK,
    2. Northup PG,
    3. Al-Osaimi AM,
    4. Caldwell SH
    Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis. J Hepatol. 2009;51(2):371-379.
    OpenUrlCrossRefPubMedWeb of Science
  9. ↵
    1. Sanyal AJ,
    2. Banas C,
    3. Sargeant C, et al.
    Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology. 2006;43(4):682-689.
    OpenUrlCrossRefPubMedWeb of Science
  10. ↵
    1. Adams LA,
    2. Lymp JF,
    3. St Sauver J, et al.
    The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005;129(1):113-121.
    OpenUrlCrossRefPubMedWeb of Science
  11. ↵
    1. Nalbantoglu IL,
    2. Brunt EM
    Role of liver biopsy in nonalcoholic fatty liver disease. World J Gastroenterol. 2014;20(27):9026-9037.
    OpenUrlPubMed
  12. ↵
    1. Ratziu V,
    2. Bellentani S,
    3. Cortez-Pinto H,
    4. Day C,
    5. Marchesini G
    A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol. 2010;53(2):372-384.
    OpenUrlCrossRefPubMedWeb of Science
  13. ↵
    1. Huang MA,
    2. Greenson JK,
    3. Chao C, et al.
    One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot study. Am J Gastroenterol. 2005;100(5):1072-1081.
    OpenUrlCrossRefPubMedWeb of Science
  14. ↵
    1. Gasteyger C,
    2. Larsen TM,
    3. Vercruysse F,
    4. Astrup A
    Effect of a dietary-induced weight loss on liver enzymes in obese subjects. Am J Clin Nutr. 2008;87(5):1141-1147.
    OpenUrlAbstract/FREE Full Text
    1. Promrat K,
    2. Kleiner DE,
    3. Niemeier HM, et al.
    Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010;51(1):121-129.
    OpenUrlCrossRefPubMedWeb of Science
  15. ↵
    1. Hickman IJ,
    2. Jonsson JR,
    3. Prins JB, et al.
    Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life. Gut. 2004;53(3):413-419.
    OpenUrlAbstract/FREE Full Text
  16. ↵
    1. Promrat K,
    2. Kleiner DE,
    3. Niemeier, et al.
    Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010;51(1):121-129.
    OpenUrlCrossRefPubMedWeb of Science
  17. ↵
    1. Mummadi RR,
    2. Kasturi KS,
    3. Chennareddygari S,
    4. Sood GK
    Effect of bariatric surgery on nonalcoholic fatty liver disease: systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2008;6(12):1396-1402.
    OpenUrlCrossRefPubMedWeb of Science
  18. ↵
    1. Day CP
    From fat to inflammation. Gastroenterology. 2006;130(1):207-210.
    OpenUrlCrossRefPubMedWeb of Science
    1. Angulo P,
    2. Machado MV,
    3. Diehl AM
    Fibrosis in nonalcoholic fatty liver disease: mechanisms and clinical implications. Semin Liver Dis. 2015;35(2):132-145.
    OpenUrlCrossRefPubMed
  19. ↵
    1. Boursier J,
    2. Diehl AM
    Implication of gut microbiota in nonalcoholic fatty liver disease. PLoS Pathog. 2015;11(1):e1004559.
    OpenUrlPubMed
  20. ↵
    1. Ratziu V,
    2. Giral P,
    3. Jacqueminet S, et al., LIDO Study Group
    Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology. 2008;135(1):100-110.
    OpenUrlCrossRefPubMedWeb of Science
    1. Aithal GP,
    2. Thomas JA,
    3. Kaye PV, et al.
    Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology. 2008;135(4):1176-1184.
    OpenUrlCrossRefPubMedWeb of Science
    1. Sanyal AJ,
    2. Chalasani N,
    3. Kowdley KV, et al., NASH CRN
    Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362(18):1675-1685.
    OpenUrlCrossRefPubMedWeb of Science
    1. Belfort R,
    2. Harrison SA,
    3. Brown K, et al.
    A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med. 2006;355(22):2297-2307.
    OpenUrlCrossRefPubMedWeb of Science
  21. ↵
    1. Torres DM,
    2. Jones FJ,
    3. Williams CD,
    4. Harrison S
    The effect of 48 weeks of rosiglitazone alone versus combination rosiglitazone and metformin (Avandamet) versus combination rosiglitzone and losartan in treatment of nonalcoholic steatohepatitis (NASH): a open-label prospective randomized clinical trial. Hepatology. 2009;50(4):390A-319A.
    OpenUrl
  22. ↵
    1. Sanyal AJ,
    2. Chalasani N,
    3. Kowdley KV, et al., NASH CRN
    Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362(18):1675-1685.
    OpenUrlCrossRefPubMedWeb of Science
  23. ↵
    1. Neuschwander-Tetri BA,
    2. Loomba R,
    3. Sanyal AJ, et al., NASH Clinical Research Network
    Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet. 2015;385(9972):956-965.
    OpenUrlCrossRefPubMed
  24. ↵
    1. Laurin J,
    2. Lindor KD,
    3. Crippin JS, et al.
    Ursodeoxycholic acid or clofibrate in the treatment of non-alcohol-induced steatohepatitis: a pilot study. Hepatology. 1996;23(6):1464-1467.
    OpenUrlCrossRefPubMedWeb of Science
  25. ↵
    1. Vuppalanchi R,
    2. Chalasani N
    Statins for hyperlipidemia in patients with chronic liver disease: are they safe? Clin Gastroenterol Hepatol. 2006;4(7):838-839.
    OpenUrlCrossRefPubMedWeb of Science
  26. ↵
    1. Bugianesi E,
    2. Gentilcore E,
    3. Manini R, et al.
    A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am J Gastroenterol. 2005;100(5):1082-1090.
    OpenUrlCrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

North Carolina Medical Journal: 77 (3)
North Carolina Medical Journal
Vol. 77, Issue 3
May-June 2016
  • Table of Contents
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on North Carolina Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Nonalcoholic Fatty Liver Disease
(Your Name) has sent you a message from North Carolina Medical Journal
(Your Name) thought you would like to see the North Carolina Medical Journal web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
1 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Nonalcoholic Fatty Liver Disease
Tyler Thrasher, Manal F. Abdelmalek
North Carolina Medical Journal May 2016, 77 (3) 216-219; DOI: 10.18043/ncm.77.3.216

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Nonalcoholic Fatty Liver Disease
Tyler Thrasher, Manal F. Abdelmalek
North Carolina Medical Journal May 2016, 77 (3) 216-219; DOI: 10.18043/ncm.77.3.216
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Clinical Presentation
    • Natural History
    • Diagnostic Evaluation
    • Current Management Strategies
    • Pharmacologic Therapies
    • Future Directives
    • Acknowledgments
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Efficacy of nanocurcumin supplementation on insulin resistance, lipids, inflammatory factors and nesfatin among obese patients with non-alcoholic fatty liver disease (NAFLD): a trial protocol
  • State of the State in Gastroenterology
  • Google Scholar

More in this TOC Section

Policy Forum

  • Health Policy Gets Personal
  • Breaking the Cycle
  • Breaking the Cycle
Show more Policy Forum

INVITED COMMENTARIES AND SIDEBARS

  • Sidebar: Community-driven Approaches to Preventing Overdoses Among American Indians
  • Sidebar: History Shaping the Future: How History Influences Health in North Carolina Native American Communities
  • Sidebar: Impact of Racial Misclassification of Health Data on American Indians in North Carolina
Show more INVITED COMMENTARIES AND SIDEBARS

Similar Articles

About & Contact

  • About the NCMJ
  • Editorial Board
  • Feedback

Info for

  • Advertisers
  • Authors
  • Reviewers
  • Subscribers

Articles & Alerts

  • Archive
  • Current Issue
  • Get Alerts
  • Upcoming Articles

Additional Content

  • Current NCIOM Task Forces
  • NC Health Data & Resources
  • NCIOM Blog
North Carolina Medical Journal

ISSN: 0029-2559

© 2022 North Carolina Medical Journal

Powered by HighWire